We have treated patients for nearly 3 years. Here is the clinical evidence for the Scrambler Therapy.

We have treated patients for nearly 3 years. Here is the clinical evidence for the Scrambler Therapy.

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Scrambler Therapy Clinical Evidence

Introduction by David Farley, MD Radiant’s Chief Medical Officer

Selected Studies

Since Scrambler Therapy is a relatively new treatment, we have provided some links to some studies that have been done.  The first is a study by Thomas J. Smith, M.D., The Harry J. Duffey Family Professor of Palliative Medicine at Johns Hopkins Medical School on Scrambler Therapy and chemotherapy induced peripheral neuropathy (CIPN).  The second is a study by Dr. Smith comparing the effectiveness of Scrambler Therapy to conventional medication management.  The third is a study by Charles Loprinzi, M.D., The Regis Professor of Breast Cancer Research at The Mayo Clinic on the effectiveness of Scrambler Therapy on CIPN.  The fourth is a review article by Dr. Loprinzi on all of the studies on Scrambler Therapy that have been published to date.  All of the studies thus far have been pilot studies with small numbers.  We have included the links to the studies by Smith and Loprinzi because, despite being pilot studies with relatively small numbers, they were well designed, done by trained personnel and under the supervision of professors with a stellar record for well-performed studies.  There are several ongoing studies both at Hopkins and at Mayo that will provide additional data.

Since there is a significant amount of technique involved, some of the studies listed in Dr. Loprinzi’s review did not show good results because the individuals performing the treatment of Scrambler Therapy were never properly trained and therefore had poor success.  This is a crucial point when evaluating a study.  The questions always have to be asked, “Who trained the technicians and how much experience do they have?”  In a sense, studies looking at Scrambler Therapy are much more akin to studies on surgery rather than medication trials, because technique is a huge part of it.  It doesn’t much matter how you take a pill, but how Scrambler Therapy is applied makes all the difference in effectiveness of treatment.  This is also why placebo controlled trials are probably not realistic, as there is a certain pattern of sensation that we are looking for in the patient to know that lead placement is correct.  That requires a lot of interaction between the technician and the patient.  If we don’t get the pattern of sensation we are looking for, we turn off the device, change lead placement, and start again.  It would be nearly impossible to do that kind of a trial against placebo, so the best studies will be the ones where Scrambler Therapy is compared to some other already accepted and well known treatment, such as the study Dr. Smith did comparing Scrambler Therapy to standard drug therapy.

At Radiant, we are getting better results than any of the studies because we have the best trained technicians under physician supervision.  Our lead technician has been treating patients for nearly 3 years now.  None of the studies performed thus far can make that claim, except, perhaps some of the groups in Italy that have trained directly under Professor Marineo as just as our lead technician has.  Although we have not done any clinical studies, we have kept good data on the patients we have treated and the results are shown below.

Published Studies:

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